Bioprotein has been identified as one of the main contents of Cellmax™. This bioprotein contains activated growth factors that support skin repair, regenerate cells, induce vascularizations and promote skin rejuvenation.

Bioprotein Content
Function
Chemokines Direct migration of white blood cells to damaged or ruptured tissues
Pro-inflammatory Cytokines Regulate growth, cell activation, differentiation and homing of the
immune cells to the sites of infection
Anti-inflammatory Cytokines Control pro-inflammatory response
Growth Factors
Fibroblast Growth Factor 2 (FGF2) Prevents endothelial cells from undergoing cell death and promotes endothelial cell proliferation and angiogenesis
Transforming Growth Factor Beta 1 (TGFβ1) Stimulating angiogenesis, fibroblast proliferation, collagen synthesis and deposition and remodeling of the new extracellular matrix
Vascular Endothelial Growth Factor A (VEGF A) Stimulates wound healing through angiogenesis and promotes collagen deposition and epithelialization

Learn how to use Cellmax™ Freeze Dried Powder and the application method
(For use by Healthcare Professionals only)

a) All previous dressing must be removed from the wounds. Then, follow a standard wound care procedure which include wound debridement

b) Wound debridement which includes removal of dead, necrotic material, slough, damaged, or infected tissue. This step is to ensure improvement of healing potential of the remaining healthy tissue. Removal may be surgical based on standard wound care technique.

c) Apply subcutaneous injection (SC) of Cellmax™:

  • Subcutaneous means under the skin. In this type of injection, a short needle is used to inject Cellmax™ into the tissue layer between the skin and the muscle.
  • Injection site is within 1.0 to 3.0mm from outer part of wound edge and at wound base/floor (centre of the wound).
  • Number of SC injection is based on wound area (Refer Table 2). The injection site is approximately 0.5cm-1.0cm between every injection and it follows surrounding the wound edge and/or wound base.
  • Volume (ml) of Cellmax™ used is based on the wound size area.
  • Wound size can be measured by ‘area measurement’ as described in the table.

d) After completed the above procedure, the wound can be covered with secondary dressing adequately.

Preparation Method:

a) Freeze dried CellmaxTM (2ml vials) is to be mixed with 2ml Sodium Chloride solution for astandard dose for all patients. CellmaxTM is dissolved (in clear liquid form) with no sediment.

b) Application method is by subcutaneous injection to the wound edge and this procedure is carried out by trained medical personnel in a standard clinical facility.

Non synthetic medical therapy approach to wound healing

Expedite wound recovery for patients with comorbidities

High potency, stable and easy to store

Free of cells

Cell specific therapeutic effects

Cellmax™ is currently undergoing comprehensive research comprising of in-vitro and in-vivo study in animal models as well as clinical trials in few prominent organizations in Malaysia. Patients’ wounds demonstrated significant improvement after the application of Cellmax™.

Indications

  • Traumatic Wound
  • Surgical Wound
  • Pressure Ulcer
  • Diabetic Foot Ulcer
  • Bed Sore
References

Koike, Y., Yozaki, M., Utani, A. et al. (2020) Fibroblast growth factor 2 accelerates the epithelial–mesenchymal transition in keratinocytes during wound 
healing process. Sci Rep 10, 18545.

Barrientos, S., Stojadinovic, O., Golinko, M.S., Brem, H. and Tomic-Canic, M. (2008), PERSPECTIVE ARTICLE: Growth factors and cytokines in wound 
healing. Wound Repair and Regeneration, 16: 585-601.

Bao, P., Kodra, A., Tomic-Canic, M., Golinko, M. S., Ehrlich, H. P., & Brem, H. (2009). The role of vascular endothelial growth factor in wound healing.
The Journal of Surgical Research, 153(2), 347–358.

Ferrara, N., Houck, K., Jakeman, L., & Leung, D. W. (1992). Molecular and biological properties of the vascular endothelial growth factor family of 
proteins. Endocrine reviews, 13(1), 18–32.

Abbasi-Malati, Zahra & Mohammadi Roushandeh, Amaneh & Kuwahara, Yoshikazu & Habibi Roudkenar, Mehryar. (2018). Mesenchymal Stem Cells on 
Horizon: A New Arsenal of Therapeutic Agents. Stem Cell Reviews and Reports. 14. 10.1007/s12015-018-9817-x.

Eleuteri S, Fierabracci A. (2019) Insights into the Secretome of Mesenchymal Stem Cells and Its Potential Applications. Int J Mol Sci. 2019
Sep 17;20(18):4597.

Cellmax™ offers a paradigm shift in wound care manegement with the emerging role of MSCs-derived secretome in cell-free therapy.

Cell-free therapy uses secreted products (secretome) from stem cells as an innovative approach to promote several biological functions, such as angiogenesis, neovascularization and arteriogenesis¹.

Secretome is defined as a range of bioprotein and bioactive substances produced by a cell in the extracellular space, which includes but is not limited to proteins, nucleic acids, proteasomes,exosomes, mciroRNA and membrane vesicles².

Cellmax™ provides an excellent treatment option for wound care management by accelerating angiogenesis, fibroblast proliferation, collagen synthesis and epithelization ³, ⁴, ⁵.

References
  1. Tan, M.I.; Alfarafifisa, N.M. Septiani, P.; Barlian, A.; Firmansyah, M.; Faizal, A.; Melani, L. Nugrahapraja, H. Potential Cell-Based and Cell-Free Therapy for Patients with COVID-19. Cells 2022, 11, 2319. https://doi.org/10.3390/cells11152319
  1. Ibrahim R, Mndlovu H, Kumar P, Adeyemi SA, Choonara YE. Cell Secretome Strategies for Controlled Drug Delivery and Wound-Healing Applications. Polymers (Basel). 2022 Jul 20;14(14):2929. doi: 10.3390/polym14142929. PMID: 35890705; PMCID: PMC9324118
  1. Barrientos, S., Stojadinovic, O., Golinko, M.S., Brem, H. and Tomic-Canic, M. (2008), PERSPECTIVE ARTICLE: Growth factors and cytokines in wound healing. Wound Repair and Regeneration, 16: 585-601.
  1. Bao, P., Kodra, A., Tomic-Canic, M., Golinko, M. S., Ehrlich, H. P., & Brem, H. (2009). The role of vascular endothelial growth factor in wound healing. The Journal of Surgical Research, 153(2), 347–358.
  1. Ferrara, N., Houck, K., Jakeman, L., & Leung, D. W. (1992). Molecular and biological properties of the vascular endothelial growth factor family of proteins. Endocrine reviews, 13(1), 18–32.

Image reproduced under an open access license from Ahangar et al., Copyright 2020, © Authors. Ahangar, P.; Mills, S.J.; Cowin, A.J. Mesenchymal stem cell secretome as an emerging cell-free alternative for improving wound repair. Int. J. Mol. Sci. 2020, 21, 7038.